ai.nullary/nullary · v1.0.1 · health-and-science
ai.nullary/nullary is healthy: it completed an MCP handshake in 457 ms and exposes 35 tools. It scores 65/100.
Negative results intelligence for drug discovery — query measured failures via MCP.
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Healthy · last checked 2026-10-14T09:15:32.359Z UTC
| Checked (UTC) | Status | Latency |
|---|---|---|
| 2026-10-14T09:15:32.359Z | ok | 457 ms |
| health | 24.2 / 25 |
| authEase | 15 / 15 |
| toolQuality | 15 / 15 |
| maintenance | 3 / 15 |
| adoption | 0 / 10 |
| usage | 0 / 10 |
| security | 8 / 10 |
search_inactive_compounds Inactive small-molecule compound-target pairs.search_failed_selectivity Small molecules that failed selectivity.search_admet_failures Small-molecule ADMET failures.search_failed_guides Failed/ineffective CRISPR guides.search_failed_essentiality_screens Non-dependency / failed essentiality screens.search_ancestry_specific_failures Ancestry-specific CRISPR failures.search_developability_failures Antibody developability failures.search_failed_clinical_antibodies Discontinued/terminated clinical antibodies.search_failed_peptide_therapeutics Failed peptide therapeutics.search_peptide_stability_issues Peptide stability/half-life failures.search_failed_protacs PROTACs that failed degradation/ternary/permeability.search_protac_e3_issues PROTAC E3-ligase recruitment / ternary failures.search_failed_oligonucleotides ASOs/siRNAs that failed engagement/developability.search_oligo_delivery_failures Oligonucleotide delivery failures.search_failed_vaccines Failed/terminated vaccines (by pathogen/indication).search_vaccine_immunogenicity_failures Failed vaccine immunogen designs.search_failed_adcs ADCs that failed at any stage.search_adc_linker_failures ADC failures attributed to linker chemistry.search_failed_bispecifics Bispecifics that failed at any stage.search_bispecific_format_failures Bispecific format/engineering failures.search_admet_failures_all_modalities ADMET failures across ALL modalities.search_drug_drug_interaction_failures Drug-drug interaction failures.search_mechanism_failures Approaches that failed for a mechanism (by target).search_failed_replications Findings that failed to replicate.search_safety_failures Clinical/preclinical safety failures across modalities.search_target_history ALL failed approaches against a target across every modality.search_indication_history ALL failed approaches for an indication across every modality.search_pathogen_history Vaccine + antimicrobial + antibody failures for a pathogen.get_compound A compound (structure, name, max clinical phase) + its full negative profile across modalities/sources.get_finding_provenance Full provenance + detail for a single finding by id.get_target_landscape Target 'graveyard' / exhaustion index: how many distinct compounds/agents have been tried against a target and failed, broken down by modality and outcome. Answers 'how picked-over is this target?'. Accepts a gene symbol (e.g. EGFR) or a UniProt accession (e.g. P00533).list_top_targets Coverage browse: the most heavily-pursued ('graveyard') targets, ranked by recorded negative findings. Optional family filter (kinase, gpcr, protease, nuclear_receptor, ion_channel, transporter, phosphatase, other).list_models Summary of the Layer-1 inactivity-scoring model registry: how many per-target models, split by family, and median scaffold-split ROC-AUC.get_model_card Per-target Layer-1 model card: training counts and held-out scaffold-split metrics (ROC-AUC, PR-AUC, Brier, calibration). Accepts a gene symbol (e.g. EGFR) or UniProt accession (e.g. P00533).get_coverage Per-modality and per-source coverage stats (honest Phase-1 numbers).