io.github.cyanheads/uniprot-mcp-server

io.github.cyanheads/uniprot-mcp-server · v0.2.6 · finance-and-payments

io.github.cyanheads/uniprot-mcp-server is healthy: it completed an MCP handshake in 337 ms and exposes 6 tools.

Protein research over UniProtKB: search by function, fetch curated records, map IDs, proteomes.

Endpoint: https://uniprot.caseyjhand.com/mcp (streamable-http)

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Facts

Users (last 30 days)0
HandshakeHealthy
Auth neededNone
Tool count6
Latency337 ms
Last checked (UTC)2026-10-16T07:20:36.489Z

Health history

Checked (UTC)StatusLatencyError
2026-10-16T07:20:36.489ZHealthy337
2026-10-15T03:25:51.182ZHealthy2705

Tools (6)

uniprot_search_proteinsSearch UniProtKB and return curated protein records. Pass text_search for a plain-language query (the 80% case) or query for the full Lucene field syntax (gene:TP53 AND organism_id:9606 AND reviewed:true) — exactly one is required. Reviewed (Swiss-Prot) entries are manually curated; unreviewed (TrEM
uniprot_get_entryFetch full curated UniProtKB entries by accession in one batch (up to 20). Each entry carries function, catalytic activity, cofactors, subcellular location, disease involvement, PTMs, natural variants, isoforms, domains, GO terms, keywords, and cross-references. Partial failures do not abort the bat
uniprot_map_idsTranslate identifiers across databases via UniProt's ID-mapping service — gene names to accessions, accession to PDB / Ensembl / RefSeq / ChEMBL / GeneID, and back. The job runs asynchronously; this tool submits it and polls within a budget. A running job returns status "running" with a ticket; pass
uniprot_get_proteomeFetch the reference proteome for an organism by UPID (e.g. "UP000005640") or NCBI taxon ID (e.g. 9606) — provide exactly one. Returns metadata inline: proteome type, total protein count, BUSCO completeness (score, complete/fragmented/missing counts, lineage dataset), and the genome assembly accessio
uniprot_get_taxonomyResolve a taxonomy record by NCBI taxon ID (e.g. 9606) or scientific name (e.g. "Homo sapiens") — provide exactly one. Returns the scientific and common name, mnemonic, rank, parent, and the full lineage. Set include_children to also fetch immediate child taxa (a separate lookup — not inline on the
uniprot_get_sequenceFetch the canonical amino-acid sequence (FASTA) for a UniProtKB accession, with length and the parsed header. Set include_isoforms to also return the alternatively-spliced isoform sequences. This is the cheap sequence-only path — for the full functional record use uniprot_get_entry. A merged accessi