net.genebe/genebe-mcp · v0.1.0 · ai-and-media
GeneBe is healthy: it completed an MCP handshake in 1141 ms and exposes 6 tools.
Annotate and classify human genetic variants with GeneBe (ACMG, gnomAD, ClinVar). Research use only.
Endpoint: https://mcp.genebe.net/v1/mcp (streamable-http)
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| Users (last 30 days) | 0 |
| Handshake | Healthy |
| Auth needed | None |
| Tool count | 6 |
| Latency | 1141 ms |
| Last checked (UTC) | 2026-10-22T16:55:11.084Z |
| Checked (UTC) | Status | Latency | Error |
|---|---|---|---|
| 2026-10-22T16:55:11.084Z | Healthy | 1141 |
annotate_variant | Annotate and classify one human genetic variant using GeneBe. Start here for any question about a variant (what is it, is it pathogenic/benign, how common is it). Returns the ACMG verdict with points and criteria, population frequency (gnomAD), predictor scores (REVEL, AlphaMissense, SpliceAI, ...) |
explain_acmg_decision_path | Explain step by step why each classification criterion did or did not apply to a variant. Use after annotate_variant when the user asks "why was this classified that way?". Returns an ASCII rendering of the decision tree with the evaluated conditions. By default it explains the germline ACMG verdic |
convert_variant | Convert a variant written in any notation into normalized hg38 genomic coordinates. Use when you only need the chr/pos/ref/alt of a variant (for example to translate HGVS or an rsID), without annotation. Does not classify the variant; use annotate_variant for that. |
get_variant_effects | List a variant's predicted molecular consequences on every overlapping transcript. Returns per-transcript HGVS (c. and p.), consequence terms (e.g. missense_variant) and impact, most severe and MANE Select transcripts first. Lightweight: no frequencies or classification. |
get_gene | Look up a human gene: identifiers, location, MANE Select transcript, ClinGen gene-disease validity. Use for questions about a gene rather than a specific variant. Transcripts are listed with MANE Select first and capped; check total_transcripts. |
liftover_coordinate | Convert a genomic position, interval or variant between genome builds (hg19, hg38, t2t). Check `status`: RESOLVED means one result, AMBIGUOUS means several candidates, anything else means it could not be mapped (see errors). For variants, ref/alt are rebuilt against the target reference and warning |