world.sniff/sniff-mcp · v1.1.0 · health-and-science
world.sniff/sniff-mcp is healthy: it completed an MCP handshake in 3271 ms and exposes 18 tools.
Canine genomics for agents: breed allele frequencies, AI pathogenicity + OMIA clinical disease layer
Endpoint: https://mcp.sniff.world/mcp/ (streamable-http)
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| Users (last 30 days) | 0 |
| Handshake | Healthy |
| Auth needed | None |
| Tool count | 18 |
| Latency | 3271 ms |
| Last checked (UTC) | 2026-10-15T14:10:12.349Z |
| Checked (UTC) | Status | Latency | Error |
|---|---|---|---|
| 2026-10-15T14:10:12.349Z | Healthy | 3271 |
ask | Ask Sniff a natural-language canine-genetics question and get a GROUNDED, CITED answer (or an honest abstain). Covers inherited diseases (OMIA) and their human homologs (the dog<->human disease bridge), breed disease/carrier risk, variant pathogenicity grades (AVCG; Boeykens et al. 2024, curated in |
ask_the_graph | THE INSTRUMENT — ask a free-form CROSS-SPECIES genetics question and get FILTERED, HONEST HINTS (never a confident guess). It compiles your question into a typed query plan over the dog<->human edge-graph, runs it deterministically, and scores each answer PATH by its weakest edge — returning ranked |
disease_bridge | The fused OMIA disease layer as cited atoms. Give a `disease` (name or 'OMIA:001870-9615') for its genes, inheritance, human homolog (OMIM/Mondo bridge), and variant pathogenicity grade (AVCG, ACMG/AMP 5-tier, curated in OMIA) when graded. Or give a `breed` (e.g. 'doberman_pinscher') for the inherit |
ask_variant_context | THE headline query. Given a CanFam4 position (e.g. '5:56189113'), return the variant's global + popmax frequency, breed-stratified cross-breed frequencies, Pangolin and phyloP annotations, gene context, linked diseases (v1.1), provenance, and deep links — in one call. Pass breed_context to also get |
variant_lookup | Single-variant lookup by CanFam4 position: ref/alt, global + popmax AF, consequence, gene, Pangolin and phyloP annotations, canonical URL, provenance. |
breed_variant_frequency | Breed-stratified allele frequency. Give a breed (e.g. 'bernese_mountain_dog') plus either a variant position or a gene symbol. Returns AF (+ rank) for the variant, or per-variant AFs in the gene. |
gene_summary | Variants in a gene (by gene symbol), ranked by impact then allele frequency. Paginated (limit, default 25); returns total_variants. Use af_min to filter by global AF. |
breed_summary | Breed profile: n_dogs, breed group, genetic geometry and nearest breeds. Descriptive only — not a health ranking. |
variant_search | Filtered discovery over all 9.67M variants. Predicates (combine freely): phylop_min (phyloP >=), popmax_min (popmax AF >=), gene_in (list of gene symbols), consequence, impact (HIGH/MODERATE/LOW/MODIFIER). Returns total_count + a capped list (max 200). Note: popmax may be in a wild population (dingo |
nearest_breeds | Genetically nearest breeds to the given breed (top-10-PC Euclidean in canine genetic space). Answers 'what breeds are most genetically similar to X?' via the PCA-256 breed co-embedding. |
breed_similarity | Genetic distance between two breeds (top-10-PC Euclidean). Lower = more genetically similar. |
semantic_search | Faceted hybrid + semantic-ranker search over the whole knowledge base (diseases, breeds, Scout discoveries). Use for fuzzy/thematic intent ('drug sensitivity in herding dogs', 'breeds prone to eye disease', 'genetically diverse breeds'). entity_type filters to 'disease'|'breed'|'discovery'. filters |
disease_links | A canine inherited disease (name or OMIA id) -> its governed OMIA clinical record: mode of inheritance, causal gene(s), curated description (summary / clinical features / molecular genetics / pathology / prevalence), clinical signs as HP/MP phenotype terms (-> Monarch), the human OMIM analog + Mondo |
disease_lookup | Look up a canine inherited disease by name or OMIA id -> its governed OMIA clinical record (inheritance, causal gene(s), curated description, clinical signs, human OMIM analog + Mondo id, evidence base). Sourced to OMIA (CC-BY); returns a canonical sniff.world URL. Dog-only. For candidate disambigua |
search_diseases | Search the canine disease catalogue by free text -> ranked candidates [{omia_id, disease, url, score}]. Use before disease_lookup when the exact name is unknown. Dog-only. |
breeds_in_atlas | List all 188 breeds with breed-stratified frequencies in the atlas. |
genes_indexed | Top genes by number of variants in the atlas (discovery aid). |
metadata | Atlas metadata: release, DOI, assembly, variant/breed counts, scope banner, and the RPC catalog. |